Ontology highlight
ABSTRACT:
SUBMITTER: Longo DM
PROVIDER: S-EPMC3694842 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Longo Diane M DM Selimkhanov Jangir J Kearns Jeffrey D JD Hasty Jeff J Hoffmann Alexander A Tsimring Lev S LS
PLoS computational biology 20130627 6
Many cellular stress-responsive signaling systems exhibit highly dynamic behavior with oscillatory features mediated by delayed negative feedback loops. What remains unclear is whether oscillatory behavior is the basis for a signaling code based on frequency modulation (FM) or whether the negative feedback control modules have evolved to fulfill other functional requirements. Here, we use experimentally calibrated computational models to interrogate the negative feedback loops that regulate the ...[more]