Ontology highlight
ABSTRACT:
SUBMITTER: Elkan-Miller T
PROVIDER: S-EPMC3071727 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Elkan-Miller Tal T Ulitsky Igor I Hertzano Ronna R Rudnicki Anya A Dror Amiel A AA Lenz Danielle R DR Elkon Ran R Irmler Martin M Beckers Johannes J Shamir Ron R Avraham Karen B KB
PloS one 20110405 4
We have employed a novel approach for the identification of functionally important microRNA (miRNA)-target interactions, integrating miRNA, transcriptome and proteome profiles and advanced in silico analysis using the FAME algorithm. Since miRNAs play a crucial role in the inner ear, demonstrated by the discovery of mutations in a miRNA leading to human and mouse deafness, we applied this approach to microdissected auditory and vestibular sensory epithelia. We detected the expression of 157 miRN ...[more]