Proteomics,Multiomics

Dataset Information

0

Inner ear proteomics/transcriptomics

ABSTRACT: The correlation between expression levels of mRNA and protein in mammals is relatively low, with a Pearson correlation coefficient of ~0.40. Post transcriptional regulation contributes to this low correlation. Across taxa, it was demonstrated that translation efficiency, i.e. the protein-to-mRNA ratio in steady state, varies between species in a direction that buffers the protein levels from changes in the transcript abundance. Evidence for this behavior in tissues is sparse. We asked whether this phenomenon is evident in our auditory system data, and on previously obtained proteomic and transcriptomic data from different tissue datasets.

OTHER RELATED OMICS DATASETS IN: PRJNA306479

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Sensory Epithelial Cell, Inner Ear

SUBMITTER: Yair Pozniak  

LAB HEAD: Tamar Geiger

PROVIDER: PXD003379 | Pride | 2017-04-24

REPOSITORIES: Pride

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Dataset's files

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Action DRS
20130531_YP_COLLAB_YONI_C15_11.raw Raw
20130531_YP_COLLAB_YONI_C15_3.raw Raw
20130531_YP_COLLAB_YONI_C15_4.raw Raw
20130531_YP_COLLAB_YONI_C15_5.raw Raw
20130531_YP_COLLAB_YONI_C15_6.raw Raw
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Publications

Reduced changes in protein compared to mRNA levels across non-proliferating tissues.

Perl Kobi K   Ushakov Kathy K   Pozniak Yair Y   Yizhar-Barnea Ofer O   Bhonker Yoni Y   Shivatzki Shaked S   Geiger Tamar T   Avraham Karen B KB   Shamir Ron R  

BMC genomics 20170418 1

<h4>Background</h4>The quantitative relations between RNA and protein are fundamental to biology and are still not fully understood. Across taxa, it was demonstrated that the protein-to-mRNA ratio in steady state varies in a direction that lessens the change in protein levels as a result of changes in the transcript abundance. Evidence for this behavior in tissues is sparse. We tested this phenomenon in new data that we produced for the mouse auditory system, and in previously published tissue d  ...[more]

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