Ontology highlight
ABSTRACT:
SUBMITTER: Ramonet D
PROVIDER: S-EPMC3071839 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Ramonet David D Daher João Paulo L JP Lin Brian M BM Stafa Klodjan K Kim Jaekwang J Banerjee Rebecca R Westerlund Marie M Pletnikova Olga O Glauser Liliane L Yang Lichuan L Liu Ying Y Swing Deborah A DA Beal M Flint MF Troncoso Juan C JC McCaffery J Michael JM Jenkins Nancy A NA Copeland Neal G NG Galter Dagmar D Thomas Bobby B Lee Michael K MK Dawson Ted M TM Dawson Valina L VL Moore Darren J DJ
PloS one 20110406 4
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical features that are largely indistinguishable from idiopathic disease. Currently, transgenic mice expressing wild-type or disease-causing mutants of LRRK2 have failed to produce overt neurodegeneration, although abnormalities in nigrostriatal dopam ...[more]