Ontology highlight
ABSTRACT:
SUBMITTER: Yue M
PROVIDER: S-EPMC4526103 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Yue M M Hinkle K M KM Davies P P Trushina E E Fiesel F C FC Christenson T A TA Schroeder A S AS Zhang L L Bowles E E Behrouz B B Lincoln S J SJ Beevers J E JE Milnerwood A J AJ Kurti A A McLean P J PJ Fryer J D JD Springer W W Dickson D W DW Farrer M J MJ Melrose H L HL
Neurobiology of disease 20150331
Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully determined but evidence points towards LRRK2 mutations causing a gain in kinase function, impacting on neuronal maintenance, vesicular dynamics and neurotransmitter release. To explore the role of physiological levels of mutant LRRK2, we created knock-in (KI) mice harboring the most common LRRK2 mutation G2019S in their own g ...[more]