Ontology highlight
ABSTRACT:
SUBMITTER: Zheng H
PROVIDER: S-EPMC3072105 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Zheng Hui H Liu Weiran W Anderson Lingyan Y LY Jiang Qiu-Xing QX
Nature communications 20110101
Recent studies hypothesized that phospholipids stabilize two voltage-sensing arginine residues of certain voltage-gated potassium channels in activated conformations. It remains unclear how lipids directly affect these channels. Here, by examining the conformations of the KvAP in different lipids, we showed that without voltage change, the voltage-sensor domains switched from the activated to the resting state when their surrounding lipids were changed from phospholipids to nonphospholipids. Suc ...[more]