Ontology highlight
ABSTRACT:
SUBMITTER: Faure E
PROVIDER: S-EPMC4047412 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20140417 23
As all integral membrane proteins, voltage-gated ion channels are embedded in a lipid matrix that regulates their channel behavior either by physicochemical properties or by direct binding. Because manipulation of the lipid composition in cells is difficult, we investigated the influence of different lipids on purified KvAP channels reconstituted in planar lipid bilayers of known composition. Lipids developed two distinct and independent effects on the KvAP channels; lipids interacting with the ...[more]