Ontology highlight
ABSTRACT:
SUBMITTER: Fogelgren B
PROVIDER: S-EPMC3072367 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Fogelgren Ben B Lin Shin-Yi SY Zuo Xiaofeng X Jaffe Kimberly M KM Park Kwon Moo KM Reichert Ryan J RJ Bell P Darwin PD Burdine Rebecca D RD Lipschutz Joshua H JH
PLoS genetics 20110407 4
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of renal cysts that destroy the kidney. Mutations in PKD1 and PKD2, encoding polycystins-1 and -2, cause ADPKD. Polycystins are thought to function in primary cilia, but it is not well understood how these and other proteins are targeted to cilia. Here, we provide the first genetic and biochemical link between polycystins and the exocyst, a highly-conserved eight-protein membrane trafficking complex. We show that ...[more]