Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC5241887 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20170118
The exocyst complex is a heterooctameric protein complex composed of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84. This complex plays an essential role in trafficking secretory vesicles to the plasma membrane through its interaction with phosphatidylinositol 4,5-bisphosphate and small GTPases. To date, the near-full-length structural information of each subunit has been limited to Exo70, although the C-terminal half structures of Sec6, Sec15 and Exo84 and the structures of the small GTP ...[more]