Ontology highlight
ABSTRACT:
SUBMITTER: Snelgrove RJ
PROVIDER: S-EPMC3072752 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Snelgrove Robert J RJ Jackson Patricia L PL Hardison Matthew T MT Noerager Brett D BD Kinloch Andrew A Gaggar Amit A Shastry Suresh S Rowe Steven M SM Shim Yun M YM Hussell Tracy T Blalock J Edwin JE
Science (New York, N.Y.) 20100902 6000
Leukotriene A(4) hydrolase (LTA(4)H) is a proinflammatory enzyme that generates the inflammatory mediator leukotriene B(4) (LTB(4)). LTA(4)H also possesses aminopeptidase activity with unknown substrate and physiological importance; we identified the neutrophil chemoattractant proline-glycine-proline (PGP) as this physiological substrate. PGP is a biomarker for chronic obstructive pulmonary disease (COPD) and is implicated in neutrophil persistence in the lung. In acute neutrophil-driven inflamm ...[more]