Ontology highlight
ABSTRACT:
SUBMITTER: Koss CK
PROVIDER: S-EPMC7870940 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Koss Carolin K CK Wohnhaas Christian T CT Baker Jonathan R JR Tilp Cornelia C Przibilla Michèl M Lerner Carmen C Frey Silvia S Keck Martina M Williams Cara M M CMM Peter Daniel D Ramanujam Meera M Fine Jay J Gantner Florian F Thomas Matthew M Barnes Peter J PJ Donnelly Louise E LE El Kasmi Karim C KC
Communications biology 20210208 1
IL-36, which belongs to the IL-1 superfamily, is increasingly linked to neutrophilic inflammation. Here, we combined in vivo and in vitro approaches using primary mouse and human cells, as well as, acute and chronic mouse models of lung inflammation to provide mechanistic insight into the intercellular signaling pathways and mechanisms through which IL-36 promotes lung inflammation. IL-36 receptor deficient mice exposed to cigarette smoke or cigarette smoke and H1N1 influenza virus had attenuate ...[more]