Ontology highlight
ABSTRACT:
SUBMITTER: Clark RJ
PROVIDER: S-EPMC3073735 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Clark Richard J RJ Tan Chia Chia CC Preza Gloria C GC Nemeth Elizabeta E Ganz Tomas T Craik David J DJ
Chemistry & biology 20110301 3
The peptide hormone hepcidin is a key homeostatic regulator of iron metabolism and involved in pathological regulation of iron in response to infection, inflammation, hypoxia, and anemia. It acts by binding to the iron exporter ferroportin, causing it to be internalized and degraded; however, little is known about the structure/activity relationships of the interaction of hepcidin with ferroportin. We show that there are key residues in the N-terminal region of hepcidin that influence its intera ...[more]