Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase.
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ABSTRACT:
SUBMITTER: Yu Z
PROVIDER: S-EPMC3074013 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
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Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase.
Yu Zhiguo Z Vodanovic-Jankovic Sanja S Ledeboer Nathan N Huang Sheng-Xiong SX Rajski Scott R SR Kron Michael M Shen Ben B
Organic letters 20110315 8
Lymphatic filariasis is caused by the parasitic nematodes Brugia malayi and Wuchereria bancrofti, and asparaginyl-tRNA synthetase (AsnRS) is considered an excellent antifilarial target. The discovery of three new tirandamycins (TAMs), TAM E (1), F (2), and G (3), along with TAM A (4) and B (5), from Streptomyces sp. 17944 was reported. Remarkably, 5 selectively inhibits the B. malayi AsnRS and efficiently kills the adult B. malayi parasite, representing a new lead scaffold to discover and develo ...[more]
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