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One-pot synthesis of 2-imidazolines via the ring expansion of imidoyl chlorides with aziridines.

ABSTRACT: We herein report a simple and convenient one-pot synthesis of highly substituted 2-imidazolines in a regiocontrolled and stereospecific matter through the ring expansion reaction of an imidoyl chloride with an aziridine, analogous to the Heine reaction.

SUBMITTER: Kuszpit MR

PROVIDER: S-EPMC3074022 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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One-pot synthesis of 2-imidazolines via the ring expansion of imidoyl chlorides with aziridines.

Kuszpit Michael R MR Wulff William D WD Tepe Jetze J JJ

The Journal of organic chemistry 20110314 8

We herein report a simple and convenient one-pot synthesis of highly substituted 2-imidazolines in a regiocontrolled and stereospecific matter through the ring expansion reaction of an imidoyl chloride with an aziridine, analogous to the Heine reaction. ...[more]

PMID: 21401025

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