Ontology highlight
ABSTRACT:
SUBMITTER: Schnabel K
PROVIDER: S-EPMC3075262 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Schnabel Kristin K Wu Chi-Chung CC Kurth Thomas T Weidinger Gilbert G
PloS one 20110412 4
In mammals, myocardial cell death due to infarction results in scar formation and little regenerative response. In contrast, zebrafish have a high capacity to regenerate the heart after surgical resection of myocardial tissue. However, whether zebrafish can also regenerate lesions caused by cell death has not been tested. Here, we present a simple method for induction of necrotic lesions in the adult zebrafish heart based on cryoinjury. Despite widespread tissue death and loss of cardiomyocytes ...[more]