Ontology highlight
ABSTRACT:
SUBMITTER: Meng X
PROVIDER: S-EPMC3075272 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Meng Xiaobo X Ezzati Peyman P Wilkins John A JA
PloS one 20110412 4
Epithelial mesenchymal transition (EMT) is characterized by the development of mesenchymal properties such as a fibroblast-like morphology with altered cytoskeletal organization and enhanced migratory potential. We report that the expression of podocalyxin (PODXL), a member of the CD34 family, is markedly increased during TGF-β induced EMT. PODXL is enriched on the leading edges of migrating A549 cells. Silencing of podocalyxin expression reduced cell ruffle formation, spreading, migration and a ...[more]