The structural biology of Toll-like receptors.
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ABSTRACT:
SUBMITTER: Botos I
PROVIDER: S-EPMC3075535 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
The structural biology of Toll-like receptors.
Botos Istvan I Segal David M DM Davies David R DR
Structure (London, England : 1993) 20110401 4
The membrane-bound Toll-like receptors (TLRs) trigger innate immune responses after recognition of a wide variety of pathogen-derived compounds. Despite the wide range of ligands recognized by TLRs, the receptors share a common structural framework in their extracellular, ligand-binding domains. These domains all adopt horseshoe-shaped structures built from leucine-rich repeat motifs. Typically, on ligand binding, two extracellular domains form an "m"-shaped dimer sandwiching the ligand molecule ...[more]
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