Ontology highlight
ABSTRACT:
SUBMITTER: Hermans SJ
PROVIDER: S-EPMC8921391 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Hermans Stefan J SJ Nero Tracy L TL Morton Craig J CJ Gooi Jonathan H JH Crespi Gabriela A N GAN Hancock Nancy C NC Gao Chen C Ishii Kenta K Markulić Jasmina J Parker Michael W MW
Biophysical reviews 20211118 1
Alzheimer's disease is a common and devastating age-related disease with no effective disease-modifying treatments. Human genetics has implicated a wide range of cell surface receptors as playing a role in the disease, many of which are involved in the production or clearance of neurotoxins in the brain. Amyloid precursor protein, a membrane-bound signaling molecule, is at the very heart of the disease: hereditary mutations in its gene are associated with a greatly increased risk of getting the ...[more]