Ontology highlight
ABSTRACT:
SUBMITTER: Borngraeber S
PROVIDER: S-EPMC307572 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Borngraeber Sabine S Budny Mary-Jane MJ Chiellini Grazia G Cunha-Lima Suzana T ST Togashi Marie M Webb Paul P Baxter John D JD Scanlan Thomas S TS Fletterick Robert J RJ
Proceedings of the National Academy of Sciences of the United States of America 20031212 26
Selective therapeutics for nuclear receptors would revolutionize treatment for endocrine disease. Specific control of nuclear receptor activity is challenging because the internal cavities that bind hormones can be virtually identical. Only one highly selective hormone analog is known for the thyroid receptor, GC-24, an agonist for human thyroid hormone receptor beta. The compound differs from natural hormone in benzyl, substituting for an iodine atom in the 3' position. The benzyl is too large ...[more]