Ontology highlight
ABSTRACT:
SUBMITTER: Grontved L
PROVIDER: S-EPMC6309829 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Grøntved Lars L Waterfall Joshua J JJ Kim Dong Wook DW Baek Songjoon S Sung Myong-Hee MH Zhao Li L Park Jeong Won JW Nielsen Ronni R Walker Robert L RL Zhu Yuelin J YJ Meltzer Paul S PS Hager Gordon L GL Cheng Sheue-Yann SY
Nature communications 20150428
A bimodal switch model is widely used to describe transcriptional regulation by the thyroid hormone receptor (TR). In this model, the unliganded TR forms stable, chromatin-bound complexes with transcriptional co-repressors to repress transcription. Binding of hormone dissociates co-repressors and facilitates recruitment of co-activators to activate transcription. Here we show that in addition to hormone-independent TR occupancy, ChIP-seq against endogenous TR in mouse liver tissue demonstrates c ...[more]