Ontology highlight
ABSTRACT:
SUBMITTER: Ding M
PROVIDER: S-EPMC3075947 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Biometrics 20071220 3
Most phase II screening designs available in the literature consider one treatment at a time. Each study is considered in isolation. We propose a more systematic decision-making approach to the phase II screening process. The sequential design allows for more efficiency and greater learning about treatments. The approach incorporates a Bayesian hierarchical model that allows combining information across several related studies in a formal way and improves estimation in small data sets by borrowi ...[more]