Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC5047439 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Yuan Ying Y Hess Kenneth R KR Hilsenbeck Susan G SG Gilbert Mark R MR
Clinical cancer research : an official journal of the American Association for Cancer Research 20160712 17
Despite more than two decades of publications that offer more innovative model-based designs, the classical 3 + 3 design remains the most dominant phase I trial design in practice. In this article, we introduce a new trial design, the Bayesian optimal interval (BOIN) design. The BOIN design is easy to implement in a way similar to the 3 + 3 design, but is more flexible for choosing the target toxicity rate and cohort size and yields a substantially better performance that is comparable with that ...[more]