An association analysis of the HLA gene region in latent autoimmune diabetes in adults.

ABSTRACT:

Aims/hypothesis

Pathophysiological similarities between latent autoimmune diabetes in adults (LADA) and type 1 diabetes indicate an overlap in genetic susceptibility. HLA-DRB1 and HLA-DQB1 are major susceptibility genes for type 1 diabetes but studies of these genes in LADA have been limited. Our aim was to define patterns of HLA-encoded susceptibility/protection in a large, well characterised LADA cohort, and to establish association with disease and age at diagnosis.

Materials and methods

Patients with LADA (n = 387, including 211 patients from the UK Prospective Diabetes Study) and non-diabetic control subjects (n = 327) were of British/Irish European origin. The HLA-DRB1 and -DQB1 genes were genotyped by sequence-specific PCR.

Results

As in type 1 diabetes mellitu

SUBMITTER: Desai M 

PROVIDER: S-EPMC3076207 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature