First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes.

ABSTRACT:

Objective

Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and type 2 diabetes; however, there is ongoing debate regarding the precise definition of LADA. Understanding its genetic basis is one potential strategy to gain insight into appropriate classification of this diabetes subtype.

Research design and methods

We performed the first genome-wide association study of LADA in case subjects of European ancestry versus population control subjects (n = 2,634 vs. 5,947) and compared against both case subjects with type 1 diabetes (n = 2,454 vs. 968) and type 2 diabetes (n = 2,779 vs. 10,396).

Results

The leading genetic signals were principally shared with type 1 diabetes, although we observed positive genetic corr

SUBMITTER: Cousminer DL 

PROVIDER: S-EPMC6196829 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature