Ontology highlight
ABSTRACT:
SUBMITTER: Tureyen K
PROVIDER: S-EPMC3076322 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Tureyen Kudret K Bowen Kellie K Liang Jin J Dempsey Robert J RJ Vemuganti Raghu R
Journal of neurochemistry 20110125 4
One of the limiting factors in stroke therapeutic development is the use of animal models that do not well represent the underlying medical conditions of patients. In humans, diabetes increases the risk of stroke incidence as well as post-stroke mortality. To understand the mechanisms that render diabetics to increased brain damage, we evaluated the effect of transient middle cerebral artery occlusion in adult db/db mice. The db/db mouse is a model of type-2 diabetes with four times higher blood ...[more]