Ontology highlight
ABSTRACT:
SUBMITTER: Landrette SF
PROVIDER: S-EPMC3076538 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Landrette S F SF Madera D D He F F Castilla L H LH
Leukemia 20110125 4
Cytokine signaling pathways are frequent targets of oncogenic mutations in acute myeloid leukemia (AML), promoting proliferation and survival. We have previously shown that the transcription factor PLAGL2 promotes proliferation and cooperates with the leukemia fusion protein Cbfβ-SMMHC in AML development. Here, we show that PLAGL2 upregulates expression of the thrombopoietin receptor Mpl, using two consensus sites in its proximal promoter. We also show that Mpl overexpression efficiently coopera ...[more]