Ontology highlight
ABSTRACT:
SUBMITTER: Strubberg AM
PROVIDER: S-EPMC6092695 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Strubberg Ashlee M AM Veronese Paniagua Daniel A DA Zhao Tingting T Dublin Leeran L Pritchard Thomas T Bayguinov Peter O PO Fitzpatrick James A J JAJ Madison Blair B BB
Stem cell reports 20180712 2
Intestinal epithelial stem cell (IESC) fate is promoted by two major transcriptional regulators, the TCF4/β-catenin complex and ASCL2, which drive expression of IESC-specific factors, including Lgr5, Ephb2, and Rnf43. Canonical Wnt signaling via TCF4/β-catenin directly transactivates Ascl2, which in turn auto-regulates its own expression. Conversely, Let-7 microRNAs antagonize the IESC lineage by repressing specific mRNA targets. Here, we identify the zinc finger transcription factor PLAGL2 as a ...[more]