Ontology highlight
ABSTRACT:
SUBMITTER: Ye J
PROVIDER: S-EPMC307659 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Ye Jin J Wang Chunfu C Sumpter Rhea R Brown Michael S MS Goldstein Joseph L JL Gale Michael M
Proceedings of the National Academy of Sciences of the United States of America 20031210 26
Hepatitis C virus (HCV) RNA replication depends on viral protein association with intracellular membranes, but the influence of membrane composition on viral replication is unclear. We report that HCV RNA replication and assembly of the viral replication complex require geranylgeranylation of one or more host proteins. In cultured hepatoma cells, HCV RNA replication was disrupted by treatment with lovastatin, an inhibitor of 3-hydroxy-3-methyglutaryl CoA reductase, or with an inhibitor of protei ...[more]