Ontology highlight
ABSTRACT:
SUBMITTER: Tomei L
PROVIDER: S-EPMC368780 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Tomei Licia L Altamura Sergio S Bartholomew Linda L Bisbocci Monica M Bailey Carolyn C Bosserman Michele M Cellucci Antonella A Forte Eleonora E Incitti Ilario I Orsatti Laura L Koch Uwe U De Francesco Raffaele R Olsen David B DB Carroll Steven S SS Migliaccio Giovanni G
Journal of virology 20040101 2
The RNA-dependent RNA polymerase of hepatitis C virus (HCV) is necessary for the replication of viral RNA and thus represents an attractive target for drug development. Several structural classes of nonnucleoside inhibitors (NNIs) of HCV RNA polymerase have been described, including a promising series of benzothiadiazine compounds that efficiently block replication of HCV subgenomic replicons in tissue culture. In this work we report the selection of replicons resistant to inhibition by the benz ...[more]