Ontology highlight
ABSTRACT:
SUBMITTER: Agnihotri G
PROVIDER: S-EPMC3076632 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20110207 5
N-acyl-γ-glutamyldiaminopimelic acid is a prototype ligand for Nod1. We report a detailed SAR of C(12)-γ-D-Glu-DAP. Analogues with glutaric or γ-aminobutyric acid replacing the glutamic acid show greatly attenuated Nod1-agonistic activity. Substitution of the meso-diaminopimelic (DAP) acid component with monoaminopimelic acid, L- or D-lysine, or cadaverine also results in reduced activity. The free amine on DAP is crucial. However, the N-acyl group on the D-glutamyl residue can be substituted wi ...[more]