Ontology highlight
ABSTRACT:
SUBMITTER: Panchal RG
PROVIDER: S-EPMC307671 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Panchal Rekha G RG Ruthel Gordon G Kenny Tara A TA Kallstrom George H GH Lane Douglas D Badie Shirin S SS Li Limin L Bavari Sina S Aman M Javad MJ
Proceedings of the National Academy of Sciences of the United States of America 20031212 26
The matrix protein VP40 plays a critical role in Ebola virus assembly and budding, a process that utilizes specialized membrane domains known as lipid rafts. Previous studies with purified protein suggest a role for oligomerization of VP40 in this process. Here, we demonstrate VP40 oligomers in lipid rafts of mammalian cells, virus-like particles, and in the authentic Ebola virus. By mutagenesis, we identify several critical C-terminal sequences that regulate oligomerization at the plasma membra ...[more]