Ontology highlight
ABSTRACT:
SUBMITTER: Chalmers KA
PROVIDER: S-EPMC3076756 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Chalmers Katy A KA Barker Rachel R Passmore Peter A PA Panza Francesco F Seripa Davide D Solfrizzi Vincenzo V Love Seth S Prince Jonathan A JA Kehoe Patrick G PG
International journal of molecular epidemiology and genetics 20100220 2
Alzheimer's disease (AD) is characterised by the extensive deposition of amyloid beta (Aβ) within the parenchyma and vasculature of the brain. It is hypothesised that a dysfunction in Aβ degradation and/or its removal from the brain may result in accumulation as plaques. Low density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional receptor shown to be involved in cholesterol metabolism but also the removal of Aβ from the brain. Its ability to transport Aβ from the brain to the ...[more]