Ontology highlight
ABSTRACT:
SUBMITTER: Vazquez-Higuera JL
PROVIDER: S-EPMC2837022 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Vázquez-Higuera José Luis JL Rodríguez-Rodríguez Eloy E Sánchez-Juan Pascual P Mateo Ignacio I Pozueta Ana A Martínez-García Ana A Frank Ana A Valdivieso Fernando F Berciano José J Bullido María J MJ Combarros Onofre O
BMC medical genetics 20100225
<h4>Background</h4>Interleukin (IL)-1beta is a potent proinflammatory cytokine markedly overexpressed in the brains of patients with Alzheimer's disease (AD), and also involved in development of atherosclerosis and coronary artery disease. Caspase-1 (CASP1), formerly called IL-1beta converting enzyme (ICE), mediates the cleavage of the inactive precursor of IL-1beta into the biologically active form. CASP1 genetic variation (G+7/in6A, rs501192) has been associated with susceptibility to myocardi ...[more]