Dataset Information

Functional polymorphisms in two pre-microRNAs and cancer risk: a meta-analysis.

ABSTRACT: Since the identification of two functional polymorphisms in pre-miRNAs ?miR-146a rs2910164 and miR-196a2 rsll614913), a number of studies were published in the past several years to evaluate the associations between the two SNPs and cancer risk. However, the findings remain conflicting rather than conclusive. This meta-analysis included 12 published case-control studies, 5,916 cancer patients and 6,869 control subjects for SNP rs2910164, and 6,574 cases and 7,601 controls for SNP rsll614913. The allele C of rsll614913 was associated with a significantly increased risk of overall cancers (CC vs. TT: OR=1.18; 95%CI: 1.02-1.37; CT vs. TT: OR=1.11; 95% CI: 1.02-1.21; CC/CT vs. TT: OR=1.13; 95%CI: 1.04-1.23). However, we failed to find main effects for rs2910164 on overall cancer risk in different genetic models tested, while significantly increased risk was evident among cancers other than breast (GG/GC vs. CC: OR=1.30, 95%CI: 1.03-1.64; between study heterogeneity test: P = 0.007). The two functional SNPs may represent tissue specific effect on cancer susceptibility; however, additional well-designed large studies are required for the validation of the associations.

SUBMITTER: Tian T

PROVIDER: S-EPMC3076781 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Functional polymorphisms in two pre-microRNAs and cancer risk: a meta-analysis.

Tian Tian T Xu Yan Y Dai Juncheng J Wu Jinchang J Shen Hongbing H Hu Zhibin Z

International journal of molecular epidemiology and genetics 20101005 4

Since the identification of two functional polymorphisms in pre-miRNAs ﹛miR-146a rs2910164 and miR-196a2 rsll614913), a number of studies were published in the past several years to evaluate the associations between the two SNPs and cancer risk. However, the findings remain conflicting rather than conclusive. This meta-analysis included 12 published case-control studies, 5,916 cancer patients and 6,869 control subjects for SNP rs2910164, and 6,574 cases and 7,601 controls for SNP rsll614913. The ...[more]

PMID: 21532845

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Project description:BackgroundThe association between polymorphisms on 15q25.1 and lung cancer has been widely evaluated; however, the studies have yielded contradictory results. We sought to investigate this inconsistency by performing a comprehensive meta-analysis on two polymorphisms (CHRNA3 gene: rs1051730 and AGPHD1 gene: rs8034191) on 15q25.1.MethodsData were extracted from 15 and 14 studies on polymorphisms rs1051730 and rs8034191 involving 12301/14000 and 14075/12873 lung cancer cases/controls, respectively. The random-effects model was applied, addressing heterogeneity and publication bias.ResultsThe two polymorphisms followed Hardy-Weinberg equilibrium for all studies (P>0.05). For rs1051730-G/A, carriers of A allele had a 36% increased risk for lung cancer (95% confidence interval [CI]: 1.27-1.46; P<0.0005), without heterogeneity (P = 0.258) or publication bias (P(Egger) = 0.462). For rs8034191-T/C, the allelic contrast indicated that C allele conferred a 23% increased risk for lung cancer (95% CI: 1.08-1.4; P = 0.002), with significant heterogeneity (P<0.0005), without publication bias (P(Egger) = 0.682). Subgroup analyses suggested that the between-study heterogeneity was derived from ethnicity, study design, matched information, and lung cancer subtypes. For example, the association of polymorphisms rs1051730 and rs8034191 with lung cancer was heterogeneous between Caucasians (OR = 1.32 and 1.22; 95% CI: 1.25-1.44 and 1.05-1.42; P<0.0005 and 0.008, respectively) and East Asians (OR = 1.51 and 1.03; 95% CI: 0.76-3 and 0.47-2.27; P = 0.237 and 0.934, respectively) under the allelic model, and this association was relatively strengthened under the dominant model. There was no observable publication bias for both polymorphisms.ConclusionsOur findings demonstrated that CHRNA3 gene rs1051730-A allele and AGPHD1 gene rs8034191-T allele might be risk-conferring factors for the development of lung cancer in Caucasians, but not in East-Asians.

Dataset Information

Functional polymorphisms in two pre-microRNAs and cancer risk: a meta-analysis.

Publications

Functional polymorphisms in two pre-microRNAs and cancer risk: a meta-analysis.

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