Pre-miR-27a rs895819A/G polymorphisms in cancer: a meta-analysis.

ABSTRACT:

Background

MicroRNAs (miRNAs) negatively regulate the 3' untranslated region (3'-UTR) of coding genes by suppressing translation or degrading mRNAs, and they act as oncogenes or tumor suppressors. Recently, several studies investigated the association between pre-miR-27a rs895819 polymorphism and the risks of various cancers, but the results were inconsistent.

Methodology/principal findings

We conducted a meta-analysis of 13 studies that included 6501 cancer cases and 7571 controls to address this association. Overall, this meta-analysis showed that the pre-miR-27a rs895819 A/G polymorphism was not statistically associated with cancers risk in all genetic models. In the stratified analysis by cancer types, when compared with the ancestral A allele, individuals with the variant G allele was consistently associated with reduced risks of breast cancer (OR?=?0.92, 95% CI?=?0.85-0.99), renal cell cancer (OR?=?0.81, 95% CI?=?0.67-0.97) and nasopharyngeal cancer (OR?=?0.84, 95% CI?=?0.72-0.97). Inversely, individuals with the heterozygote AG was associated with an increased risk of digestive tract cancers compared with AA genotype (AG vs. AA: OR?=?1.16, 95% CI?=?1.01-1.32). In the stratified analysis by ethnicity, the pre-miR-27a rs895819 polymorphism showed statistically significant association with decreased risks of cancers in Caucasians (G vs. A allele: OR?=?0.90, 95% CI?=?0.83-0.97; AG vs. AA: OR?=?0.84, 95% CI?=?0.75-0.94; AG/GG vs. AA: OR?=?0.85, 95% CI?=?0.76-0.94) but not in Asians.

Conclusion/significance

This meta-analysis suggests that the pre-miR-27a rs895819 polymorphism may contribute to the susceptibilities of some specific-type of cancers, including breast cancer, renal cell cancer, nasopharyngeal cancer and digestive tract cancers, as well as the susceptibilities of cancers in Caucasians to some extent.

SUBMITTER: Xu Q 

PROVIDER: S-EPMC3676439 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature