Pre-miR-27a rs895819A/G polymorphisms in cancer: a meta-analysis.

ABSTRACT:

Background

MicroRNAs (miRNAs) negatively regulate the 3' untranslated region (3'-UTR) of coding genes by suppressing translation or degrading mRNAs, and they act as oncogenes or tumor suppressors. Recently, several studies investigated the association between pre-miR-27a rs895819 polymorphism and the risks of various cancers, but the results were inconsistent.

Methodology/principal findings

We conducted a meta-analysis of 13 studies that included 6501 cancer cases and 7571 controls to address this association. Overall, this meta-analysis showed that the pre-miR-27a rs895819 A/G polymorphism was not statistically associated with cancers risk in all genetic models. In the stratified analysis by cancer types, when compared with the ancestral A allele, individuals with the varia

SUBMITTER: Xu Q 

PROVIDER: S-EPMC3676439 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature