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Total synthesis and biological evaluation of marinopyrrole A and analogues.

ABSTRACT: A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogues whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.

SUBMITTER: Nicolaou KC

PROVIDER: S-EPMC3077031 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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Total synthesis and biological evaluation of marinopyrrole A and analogues.

Nicolaou K C KC Simmons Nicholas L NL Chen Jason S JS Haste Nina M NM Nizet Victor V

Tetrahedron letters 20110401 17

A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogues whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated. ...[more]

PMID: 21499535

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