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Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues.


ABSTRACT: Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.

SUBMITTER: Zhao M 

PROVIDER: S-EPMC7237762 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues.

Zhao Meng M   Xiao Yi Y   Otsuka Satoshi S   Nakao Yoichi Y   Guo Yian Y   Ye Tao T  

Frontiers in chemistry 20200513


Kakeromamide A (<b>1</b>), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity. ...[more]

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