Microbial manipulation of receptor crosstalk in innate immunity.
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ABSTRACT:
SUBMITTER: Hajishengallis G
PROVIDER: S-EPMC3077082 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Microbial manipulation of receptor crosstalk in innate immunity.
Hajishengallis George G Lambris John D JD
Nature reviews. Immunology 20110301 3
In the arms race of host-microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses. In this Review, we focus on 'crosstalk manipulation' - the microbial strategies that instigate, subvert or disrupt the molecular signalling crosstalk between receptors of the innate immune system. This proactive interference undermines host defences and contributes to microbial adaptive fitness and persistent infections. Understanding how pathogens exploit hos ...[more]
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