Ontology highlight
ABSTRACT:
SUBMITTER: Haque N
PROVIDER: S-EPMC5861047 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Haque Nazmul N Ouda Ryota R Chen Chao C Ozato Keiko K Hogg J Robert JR
Nature communications 20180320 1
Control of type I interferon production is crucial to combat infection while preventing deleterious inflammatory responses, but the extent of the contribution of post-transcriptional mechanisms to innate immune regulation is unclear. Here, we show that human zinc finger RNA-binding protein (ZFR) represses the interferon response by regulating alternative pre-mRNA splicing. ZFR expression is tightly controlled during macrophage development; monocytes express truncated ZFR isoforms, while macropha ...[more]