Naproxen interferes with the assembly of A? oligomers implicated in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC3077692 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
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Naproxen interferes with the assembly of Aβ oligomers implicated in Alzheimer's disease.
Kim Seongwon S Chang Wenling E WE Kumar Rashmi R Klimov Dmitri K DK
Biophysical journal 20110401 8
Experimental and epidemiological studies have shown that the nonsteroidal antiinflammatory drug naproxen may be useful in the treatment of Alzheimer's disease. To investigate the interactions of naproxen with Aβ dimers, which are the smallest cytotoxic aggregated Aβ peptide species, we use united atom implicit solvent model and exhaustive replica exchange molecular dynamics. We show that naproxen ligands bind to Aβ dimer and penetrate its volume interfering with the interpeptide interactions. As ...[more]
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