Ontology highlight
ABSTRACT:
SUBMITTER: Okamura Y
PROVIDER: S-EPMC3077710 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Okamura Yosuke Y Schmidt Roman R Raschke Ines I Hintze Maik M Takeoka Shinji S Egner Alexander A Lang Thorsten T
Biophysical journal 20110401 8
Eukaryotic cells respond to signaling molecules with picomolar to nanomolar sensitivities. However, molar concentrations give no suggestion of the sufficient number of molecules per cell and are confusing when referring to physiological situations in which signaling molecules act in an immobilized state. Here, we studied platelet adhesion by thrombin, a key step in normal hemostasis and pathological arterial thrombosis. We generated a biofunctional nanosheet surface to mimic the in vivo solid-st ...[more]