Traction on immobilized netrin-1 is sufficient to reorient axons.
Ontology highlight
ABSTRACT:
SUBMITTER: Moore SW
PROVIDER: S-EPMC2746731 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Traction on immobilized netrin-1 is sufficient to reorient axons.
Moore Simon W SW Biais Nicolas N Sheetz Michael P MP
Science (New York, N.Y.) 20090701 5937
During embryonic development, axons are guided to their target by patterning proteins encountered along their trajectory. These cues can be linked to the cells that produce them or secreted into the extracellular matrix. Whether secreted cues, like netrin-1, provide traction for the growth cone when they become attached to the extracellular matrix is unclear. Advancing spinal commissural neuron growth cones were shown to generate local forces of 4 to 15 piconewtons but, when confronted with immo ...[more]
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