Ontology highlight
ABSTRACT:
SUBMITTER: Groveman BR
PROVIDER: S-EPMC3078127 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Groveman Bradley R BR Xue Sheng S Marin Vedrana V Xu Jindong J Ali Mohammad K MK Bienkiewicz Ewa A EA Yu Xian-Min XM
The FEBS journal 20101230 4
Previous studies demonstrated that intra-domain interactions between Src family kinases (SFKs), stabilized by binding of the phosphorylated C-terminus to the SH2 domain and/or binding of the SH2 kinase linker to the SH3 domain, lock the molecules in a closed conformation, disrupt the kinase active site, and inactivate SFKs. Here we report that the up-regulation of N-methyl-D-aspartate receptors (NMDARs) induced by expression of constitutively active neuronal Src (n-Src), in which the C-terminus ...[more]