Ontology highlight
ABSTRACT:
SUBMITTER: Anthis NJ
PROVIDER: S-EPMC3078336 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Trends in biochemical sciences 20110106 4
Integrins are essential adhesion receptors found on the surfaces of all metazoan cells. As regulators of cell migration and extracellular matrix assembly, these membrane-spanning heterodimers are critical for embryonic development, tissue repair and immune responses. Signals transmitted by integrins from outside to inside the cell promote cell survival and proliferation, but integrin affinity for extracellular ligands can also be controlled by intracellular cues. This bidirectional signaling is ...[more]