Ontology highlight
ABSTRACT:
SUBMITTER: Wang JB
PROVIDER: S-EPMC3078749 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Wang Jian-Bin JB Erickson Jon W JW Fuji Reina R Ramachandran Sekar S Gao Ping P Dinavahi Ramani R Wilson Kristin F KF Ambrosio Andre L B AL Dias Sandra M G SM Dang Chi V CV Cerione Richard A RA
Cancer cell 20100901 3
Rho GTPases impact a number of activities important for oncogenesis. We describe a small molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in fibroblasts, and the growth of human breast cancer and B lymphoma cells, without affecting normal cells. We identify the target of this inhibitor to be the metabolic enzyme glutaminase, which catalyzes the hydrolysis of glutamine to glutamate. We show that transformed fibroblasts and breast cancer cells exhibit elevated ...[more]