Ontology highlight
ABSTRACT:
SUBMITTER: Serasinghe MN
PROVIDER: S-EPMC4320323 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Serasinghe Madhavika N MN Wieder Shira Y SY Renault Thibaud T TT Elkholi Rana R Asciolla James J JJ Yao Jonathon L JL Jabado Omar O Hoehn Kyle K Kageyama Yusuke Y Sesaki Hiromi H Chipuk Jerry E JE
Molecular cell 20150201 3
Mitochondrial division is essential for mitosis and metazoan development, but a mechanistic role in cancer biology remains unknown. Here, we examine the direct effects of oncogenic RAS(G12V)-mediated cellular transformation on the mitochondrial dynamics machinery and observe a positive selection for dynamin-related protein 1 (DRP1), a protein required for mitochondrial network division. Loss of DRP1 prevents RAS(G12V)-induced mitochondrial dysfunction and renders cells resistant to transformatio ...[more]