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Synthetic Studies on the Ambiguine Family of Alkaloids: Construction of the ABCD Ring System.

ABSTRACT: A racemic synthesis of the ABCD ring core of the ambiguines that preserves the tertiary alcohol has been accomplished in convergent synthesis in 10 synthetic steps, in an overall yield of 46% from commercially available 4-bromoindole and m-methylanisole.

SUBMITTER: Rafferty RJ

PROVIDER: S-EPMC3079252 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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Synthetic Studies on the Ambiguine Family of Alkaloids: Construction of the ABCD Ring System.

Rafferty Ryan J RJ Williams Robert M RM

Tetrahedron letters 20110401 17

A racemic synthesis of the ABCD ring core of the ambiguines that preserves the tertiary alcohol has been accomplished in convergent synthesis in 10 synthetic steps, in an overall yield of 46% from commercially available 4-bromoindole and m-methylanisole. ...[more]

PMID: 21516192

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