Ontology highlight
ABSTRACT:
SUBMITTER: Nakahira K
PROVIDER: S-EPMC3079381 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Nakahira Kiichi K Haspel Jeffrey Adam JA Rathinam Vijay A K VA Lee Seon-Jin SJ Dolinay Tamas T Lam Hilaire C HC Englert Joshua A JA Rabinovitch Marlene M Cernadas Manuela M Kim Hong Pyo HP Fitzgerald Katherine A KA Ryter Stefan W SW Choi Augustine M K AM
Nature immunology 20101212 3
Autophagy, a cellular process for organelle and protein turnover, regulates innate immune responses. Here we demonstrate that depletion of the autophagic proteins LC3B and beclin 1 enhanced the activation of caspase-1 and secretion of interleukin 1β (IL-1β) and IL-18. Depletion of autophagic proteins promoted the accumulation of dysfunctional mitochondria and cytosolic translocation of mitochondrial DNA (mtDNA) in response to lipopolysaccharide (LPS) and ATP in macrophages. Release of mtDNA into ...[more]