Ontology highlight
ABSTRACT:
SUBMITTER: Halle A
PROVIDER: S-EPMC3101478 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Halle Annett A Hornung Veit V Petzold Gabor C GC Stewart Cameron R CR Monks Brian G BG Reinheckel Thomas T Fitzgerald Katherine A KA Latz Eicke E Moore Kathryn J KJ Golenbock Douglas T DT
Nature immunology 20080711 8
The fibrillar peptide amyloid-beta (A beta) has a chief function in the pathogenesis of Alzheimer's disease. Interleukin 1 beta (IL-1 beta) is a key cytokine in the inflammatory response to A beta. Insoluble materials such as crystals activate the inflammasome formed by the cytoplasmic receptor NALP3, which results in the release of IL-1 beta. Here we identify the NALP3 inflammasome as a sensor of A beta in a process involving the phagocytosis of A beta and subsequent lysosomal damage and releas ...[more]