Ontology highlight
ABSTRACT:
SUBMITTER: Sanders BC
PROVIDER: S-EPMC3079482 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20101223 4
Although metal-free cycloadditions of cyclooctynes and azides to give stable 1,2,3-triazoles have found wide utility in chemical biology and material sciences, there is an urgent need for faster and more versatile bioorthogonal reactions. We have found that nitrile oxides and diazocarbonyl derivatives undergo facile 1,3-dipolar cycloadditions with cyclooctynes. Cycloadditions with diazocarbonyl derivatives exhibited similar kinetics as compared to azides, whereas the reaction rates of cycloaddit ...[more]